Effects of ovulation induction on expression of integrins alpha 4 beta 1 in endometrium

To study the effect of clomiphene citrate (CC) and human menopausal gonadotropin (hMG) on the expression of integrins alpha 4 beta 1 during implantation window in endometrium.Endometrium integrin alpha 4 beta 1 expression was detected by immunohistochemistry method in the mid-secretory phase of 48 normal natural cycles. CC + hCG or CC + hMG + hCG cycles in 30 polycystic ovary syndrome (PCOS) patients and 48 normal women.The expression of endometrial integrin alpha 4 beta 1 was stronger in the natural cycles than those of ovulation induction cycles with CC + hCG or CC + hMG + hCG. So was the pregnancy cycles as compared with the non-pregnant cycles.The endometrial receptivity in the min luteal phase and pregnant rate declined during ovulation induction by CC + hCG or CC + hMG + hCG in either normal women or PCOS patients.PubMed中文核心期刊要目总览(PKU)中国科学引文数据库(CSCD)06352-43