Effects of vitamin A and iron supplementation on the improvement of iron status and immunological function in preschool children

In order to understand the changes in immunological function in rural preschool children with lower levels of vitamin A and iron, and the effect of vitamin A and iron supplementation on the improvement of iron status and immunological function.Serum vitamin A concentration and hemoglobin (Hb), serum iron (SI), transferrin saturation (TS), serum ferritin (SF) were determined in 270 rural preschool children aged 3-7 years in Beijing, and the subjects were divided into four groups based on their determinations: control, lower serum vitamin A, lower iron, and both lower iron and serum vitamin A. Forty subjects were selected from each group, and serum IgA, IgG, IgM and interleukin-2 (IL-2) were determined for them. Forty-one subjects who had lower iron and lower serum vitamin A (< 1.12 mumol/L) were divided into two groups: one of them supplemented with 30 mg iron element (ferrous sulfate 0.15 g) once a day for 8 weeks, and the other group supplemented with iron and 12,500 IU vitamin A twice a week for 8 weeks. After supplementation of vitamin A and iron, their serum vitamin A, hematological iron index and serum immunological index were determined again for the two groups.Serum IgM were (1,260 +/- 310) mg/L in both lower iron and serum vitamin A groups, significantly higher than that in normal group (1,070 +/- 170) mg/L (P < 0.05). But there were no significant differences in serum levels of IgG, IgA and IL-2. After supplementation of iron and vitamin A, their serum TS increased to (26.5 +/- 8.6)%, significantly higher than that before supplementation and that supplemented with iron only (22.3 +/- 3.8)%. And, their serum IL-2 were (278.9 +/- 117.7) ng/L after supplementation, significantly higher than that before supplementation (161.6 +/- 90.3) ng/L and that in those supplemented with iron only (189.5 +/- 89.3) ng/L. There was no significant difference in other biochemical indices of iron and immunological indices.Supplementation with vitamin A and iron was helpful to improve body iron nutritional status and immunological function obviously in preschool children with iron-deficiency and sub-clinical deficiency of vitamin A.PubMed06374-73