Effect of quercetin on the acyclovir intestinal absorption

To study the effect of quercetin on acyclovir intestinal absorption.The everted gut sac and in vitro intestinal absorption tests were performed. The acyclovir transport quantity was determined by HPLC method.The everted gut sac study showed that quercetin significantly inhibited the function of intestinal P-glycoprotein P-gp . The acyclovir transport quantities from mucosa to serosa space, which incubated with 5, 10, 80 mg/L quercetin solution or 10 mg/L verapamil solution, were increased 0.3, 0.6, 1.0 and 1.0-fold higher than acyclovir alone, respectively. The transport quantity caused by inhibition of intestinal P-gp function fitted with Boltzmann equation. The in vitro intestinal absorption test indicated that the transported acyclovir from serosa to mucosa, incubated with 2, 5, 10 mg/L quercetin solution, was significantly decreased compared with acyclovir alone.Quercetin can enhance acyclovir intestinal absorption by inhibiting the function of P-gp.PubMed03309-123