Topics
breast cancerDisease
mTORBiomolecule
carcinogenesisMilitary unit
current literatureMagazine
oncogenesisMilitary unit
rapamycinChemical substance
Background/Aim: The mammalian, or mechanistic, target of rapamycin (mTOR) pathway has been implicated in several models of human oncogenesis. Research in the role of mTOR in human oncogenesis remains a field of intense activity. In this mini-review, we intend to recount our current understanding of the mTOR pathway, its interactions, and its role in human carcinogenesis in general, and breast cancer in particular. Materials and Methods: We herein outline the discrete components of the two complexes of mTOR, and attempt to define their distinct roles and interactions. Furthermore, we review current developments in the therapeutic targeting of mTOR in human breast cancer. Results: Our understanding of the organisation and interactions of the ...
The Mechanistic or Mammalian Target of Rapamycin (mTOR) is a major signaling pathway in eukaryotic c...
The mammalian target of rapamycin (mTOR) was originally identified in yeast as the protein responsib...
The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regula...
Background/Aim: The mammalian, or mechanistic, target of rapamycin (mTOR) pathway has been implicate...
Based on the insights gleaned from decades of research, it seems clear that mechanistic target of ra...
Based on the insights gleaned from decades of research, it seems clear that mechanistic target of ra...
The mammalian target of rapamycin (mTOR) has emerged as a critical effector in cell-signaling pathwa...
The mammalian target of rapamycin (mTOR) pathway is a central pathway that regulates mRNA translatio...
Over the last decade, extensive studies have been made to understand the role played by the mammalia...
There is currently a wealth of information regarding the mutations that contribute to cancer develop...
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating ...
The mammalian target of rapamycin (mTOR) is a highly conserved serine/threonine-protein kinase, whic...
The mTOR pathway has many different effectors, and is an important regulator of cell growth, metabol...
The protein mammalian Target of Rapamycin (mTOR) is a conserved Ser-ine/Threonine kinase that regula...
Rapamycin and modified rapamycins (rapalogs) have been used to prevent allograft rejection after org...
The Mechanistic or Mammalian Target of Rapamycin (mTOR) is a major signaling pathway in eukaryotic c...
The mammalian target of rapamycin (mTOR) was originally identified in yeast as the protein responsib...
The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regula...
Background/Aim: The mammalian, or mechanistic, target of rapamycin (mTOR) pathway has been implicate...
Based on the insights gleaned from decades of research, it seems clear that mechanistic target of ra...
Based on the insights gleaned from decades of research, it seems clear that mechanistic target of ra...
The mammalian target of rapamycin (mTOR) has emerged as a critical effector in cell-signaling pathwa...
The mammalian target of rapamycin (mTOR) pathway is a central pathway that regulates mRNA translatio...
Over the last decade, extensive studies have been made to understand the role played by the mammalia...
There is currently a wealth of information regarding the mutations that contribute to cancer develop...
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating ...
The mammalian target of rapamycin (mTOR) is a highly conserved serine/threonine-protein kinase, whic...
The mTOR pathway has many different effectors, and is an important regulator of cell growth, metabol...
The protein mammalian Target of Rapamycin (mTOR) is a conserved Ser-ine/Threonine kinase that regula...
Rapamycin and modified rapamycins (rapalogs) have been used to prevent allograft rejection after org...
The Mechanistic or Mammalian Target of Rapamycin (mTOR) is a major signaling pathway in eukaryotic c...
The mammalian target of rapamycin (mTOR) was originally identified in yeast as the protein responsib...
The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regula...
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