This study investigated the efficacy of human osteoprotegerin (hOPG) transgene to accelerate osteointegration of titanium implant in ovariectomized (OVX) rats. Bone marrow stromal cells transduced with Ad-hOPG-EGFP could sustainedly express hOPG. Osteoclast precursor RAW264.7 cells treated by the hOPG were examined by tartrate-resistant acid phosphatase (TRAP) staining and bone slice resorption assay. The results showed differentiation and function of osteoclasts were significantly suppressed by hOPG in vitro. Ad-hOPG-EGFP was locally administered to the bone defect prior to implant placement in OVX and sham rats. After 3, 7, 28 days of implantation, the femurs were harvested for molecular and histological analyses. Successful transgene exp...
Calcitonin gene-related peptide (CGRP) promotes osteoblast recruitment and osteogenic activity. Howe...
Optimization of implant osseointegration in patients with reduced bone healing potential is a challe...
Platelet-derived growth factor-BB (PDGF-BB) stimulates repair of healing-impaired chronic wounds suc...
Click on the DOI link to access this articleUsing an in vivo adeno-associated virus (AAV)-mediated g...
Exogenous OPG gene modification appears a therapeutic strategy for osteolytic aseptic loosening. The...
Click on the DOI link to access the publishers version of this article (may not be free) or click on...
Objective The objective of this study was to investigate the effects of osteoprotegerin (OPG) gene ...
Cells genetically modified to produce osteoinductive factors have potential for use in enhancing bon...
Copyright © 2013 Jesse Seamon et al. This is an open access article distributed under the Creative C...
Calcitonin gene-related peptide (CGRP) promotes osteoblast recruitment and osteogenic activity. Howe...
This study investigated the efficacy of a combination gene therapy to repress IL-1 and RANKL for the...
Osteosarcoma is the most frequent primary bone tumor that develops mainly in the young, the median a...
Osteoporosis is a major and growing healthcare concern as the population ages. The genes of both a A...
The bone mineral deficiency in osteoporosis poses a threat to the long-term outcomes of endosseous i...
Click on the DOI link to access this article (may not be free)This study investigated the efficacy o...
Calcitonin gene-related peptide (CGRP) promotes osteoblast recruitment and osteogenic activity. Howe...
Optimization of implant osseointegration in patients with reduced bone healing potential is a challe...
Platelet-derived growth factor-BB (PDGF-BB) stimulates repair of healing-impaired chronic wounds suc...
Click on the DOI link to access this articleUsing an in vivo adeno-associated virus (AAV)-mediated g...
Exogenous OPG gene modification appears a therapeutic strategy for osteolytic aseptic loosening. The...
Click on the DOI link to access the publishers version of this article (may not be free) or click on...
Objective The objective of this study was to investigate the effects of osteoprotegerin (OPG) gene ...
Cells genetically modified to produce osteoinductive factors have potential for use in enhancing bon...
Copyright © 2013 Jesse Seamon et al. This is an open access article distributed under the Creative C...
Calcitonin gene-related peptide (CGRP) promotes osteoblast recruitment and osteogenic activity. Howe...
This study investigated the efficacy of a combination gene therapy to repress IL-1 and RANKL for the...
Osteosarcoma is the most frequent primary bone tumor that develops mainly in the young, the median a...
Osteoporosis is a major and growing healthcare concern as the population ages. The genes of both a A...
The bone mineral deficiency in osteoporosis poses a threat to the long-term outcomes of endosseous i...
Click on the DOI link to access this article (may not be free)This study investigated the efficacy o...
Calcitonin gene-related peptide (CGRP) promotes osteoblast recruitment and osteogenic activity. Howe...
Optimization of implant osseointegration in patients with reduced bone healing potential is a challe...
Platelet-derived growth factor-BB (PDGF-BB) stimulates repair of healing-impaired chronic wounds suc...