Compared study of vascular cell response to Mg-Zn-Y-Nd and WE43 as biodegradable stents

To evaluate biocompatibility of Mg-Zn-Y-Nd alloy as vascular stent material, its influence on cytotoxicity, cell migration, cell chemotaxis and NO release of vascular endothelial cells and vascular smooth muscle cells were tested compared with WE43 alloy. Results show that Mg-Zn-Y-Nd alloy degraded slower and exhibited better cell viability and NO release than WE43; WE43 showed more significant effect on stimulating endothelial cells' migration; Both alloys showed nonsignificant effect on vascular smooth muscle cells' migration and chemotaxis. Mg-Zn-Y-Nd alloy exhibited great biocompatibility to vascular cells. ? (2014) Trans Tech Publications, Switzerland.EI