Triphenylphosphine-N-bromosuccinimide mediated chemoselective cyclodehydration of diols

A triphenylphosphine-N-bromosuccinimide mediated chemoselective cyclodehydration of diols is presented for the synthesis of polysubstituted tetrahydrofurans. 1,4-Diols and their derivatives can be rapidly cyclized to furnish tetrahydrofurans in high yields with one equivalent of Ph3P/NBS. Higher amount of Ph3P/NBS leads to the formation of dibromobutanes. ? Georg Thieme Verlag Stuttgart ?? New York.SCI(E)EI0ARTICLEsunqi@bjmu.edu.cn; lirt@bjmu.edu.cn81154-11624