Four New Dammarane-Type Triterpene Saponins from the Stems and Leaves of Panax ginseng and Their Cytotoxicity on HL-60 Cells

Four new triterpene saponins, ginsenosides Rh-14-Rh-17 (1-4), along with two known compounds, 20(S)-ginsenoside Rg(2) and dammar-(E)-20(22),24-diene-3 beta,6 alpha,12 beta-triol, were isolated from the stems and leaves of Panax ginseng. The structures of the new compounds were elucidated as 3 beta,6 alpha,12 beta,24 xi-tetrahydroxydammar-(E)-20(22),25-diene 6-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranoside (1), 3 beta,12 beta,24 xi-trihydroxy-dammar-(E)-20 (22),25-diene 3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranoside (2), 3 beta,6 alpha,12 beta-trihydroxy-dammar-(E)-20(22),24-diene 3-O-beta-D-glucopyranoside (3), and 3-oxo-6 alpha,12 beta,20(S)-trihydroxydammar-24-ene 6-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranoside (4) by means of extensive spectroscopic and chemical methods, respectively. The isolated compounds were tested for in vitro cytotoxicity against HL-60 cells.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000299909300016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Plant SciencesChemistry, MedicinalPharmacology & PharmacySCI(E)PubMed13ARTICLE2189-1927