Combination therapy of periodontal intrabony defects with demineralized freeze-dried bone powder and platelet-rich plasma

To evaluate the effect of decalcified freeze-dried bone allograft (DFDBA) and DFDBA with platelet-rich plasma (PRP) in the treatment of periodontal infrabony defects.Fifteen periodontal infrabony defects (30 sites) in 12 patients with periodontitis (9 patients with chronic periodontitis and 3 patients with aggressive periodontitis) were selected. Three months after initial therapy, they were assigned to either the DFDBA group (10 defects with 20 sites) or the DFDBA with PRP group (5 defects with 10 sites). The patients were evaluated for plaque index (PI), bleeding index (BI), probing depths (PD) and clinical attachment loss (CAL) before the treatment and at 6 months after periodontal bone graft surgery.The PI, BI, PD and CAL in the DFDBA group were 1.7, 2.7, 6.0 mm and 7.0 mm at baseline; 1.5, 1.8, 3.9 mm and 4.4 mm at the 6 months after periodontal surgery. The PD, CAL and BI in DFDBA with PRP group at baseline were 6.2 mm, 7.1 mm and 2.9; 3.2 mm, 3.6 mm and 1.7 at the 6 months after periodontal surgery. The PI did not change significantly after surgery in both groups. While both groups showed significant improvement (P<0.01) in BI, PD and CAL, the improvement in the DFDBA with PRP group was significant greater than in the DFDBA group (P<0.05).DFDBA is an effective therapy for periodontal intrabony defects. DFDBA with PRP can significantly improve the clinical effect of periodontal infrabony defects.PubMed0124-74