A general route to the synthesis of N-protected 1-substituted and 1,2-disubstituted taurines

N-Benzyloxycarbonyl protected alpha-substituted and alpha,beta-disubstituted taurines were synthesized from olefins and epoxides via N-benzyloxycarbonylamino alcohol thioacetates as key intermediates. They are important sulfur analogues of naturally occurring amino acids and building blocks for the synthesis of alpha-substituted and alpha,beta-disubstituted beta-sulfonopeptides.Chemistry, OrganicSCI(E)EI27ARTICLE2276-28