SYNTHESIS OF POLYURETHANES CONTAINING NUCLEIC-ACID BASE DERIVATIVES AS GRAFTED PENDANTS AND THEIR PRECURSOR AMINO FUNCTIONALIZED POLYURETHANE

A new route to polyurethanes containing nucleic acid base derivatives as grafted pendants have been established. The method is based on the grafting of 2-(thymin-1-yl)propionic acid (TPA) or 2-(adenin-9-yl)propionic acid (APA), onto amino functionalized polyurethane, poly left bracket 2-amino-2-methyl-1,3-propylene methylene bis(4-phenyl carbamate) right bracket (PU-NH//2, IX) at the primary amino group by the N-hydroxy compound of active ester technique. Two novel polymer models of polynucleic acid - poly left bracket 2-(2 prime -(thymin-1 prime -yl)propionamide)-2-methyl-1,3-propylene methylene bis(4-phenylcarbamate) right bracket ; (PU-NHT, X) and poly left bracket 2-(2 prime -(adenin-9 prime -yl)propionamido)-2-methyl-1,3-propylene methylene bis(4-phenylcarbamate) right bracket (PU-NHA-40, XI) - were obtained. Prior to polymer synthesis, the amidation of APA with 3-aminoheptane or diethylamine were carried out as a model reaction study and the related monomer model compounds were prepared by the same methods.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1987L128900008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Polymer ScienceSCI(E)EI12ARTICLE123267-32812