Fixation Behavior in Primary Open Angle Glaucoma at Early and Moderate Stage Assessed by the MicroPerimeter MP-1

Purpose: Using MicroPerimetry MP-1 to assess the fixation behavior in early and moderate primary open angle glaucoma (POAG). Methods: Thirty-nine early and moderate POAG eyes and 22 normal eyes were enrolled prospectively. The stability and location of the fixation in each subject eye were recorded by the macula 10-degree program of the microperimeter (MP-1). Retinal sensitivity was examined using the G2 program phase 1 of an Octopus 101 perimeter and the macula 10-degree program of the MP-1. The fixation behavior and the retinal sensitivity were compared between POAG and control groups. The correlation between the fixation behavior and the retinal sensitivity was analyzed in POAG patients. Results: Fixation instability was detected in POAG (P = 0.016). It correlated with the mean defect on Octopus perimeter and all the mean macular sensitivity parameters of MP-1, which includes the central 10 degrees (r = 0.416, P = 0.008), 6 degrees (r = 0.401, P = 0.011), 2 degrees (r = 0.376, P = 0.018), inferotemporal (r = 0.399, P = 0.012) and inferonasal (r = 0.387, P = 0.015) quadrants of the central 6 degrees. All the POAG patients had a predominantly central fixation. Conclusion: Fixation instability manifested in early and moderate POAG eyes, which may be an early sign of POAG.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000314184300018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701OphthalmologySCI(E)PubMed5ARTICLE2169-1732