Effects of nimodipine on cochlear blood flow with normal and vertebrobasilar insufficiency status

To study effect of nimodipine (ND) on cochlear blood flow (CBF).CBF was measured in twenty-two guinea pigs by laser Doppler flowmetry(LDF).Nimodipine decreased CBF following the decrease of systemic BP and present a dose dependent mode, neither the dose of nimodipine is lower, normal and higher, nor the animal is under the status of normal supply of inner ear blood flow and ischemia of inner ear caused by vertebrobasilar insufficiency(VBI).It suggested that this compound may be of little clinical use to elevate CBF.PubMed中文核心期刊要目总览(PKU)中国科学引文数据库(CSCD)04174-61