To test whether gabapentin, an anticonvulsant, is able to inhibit responses to peritoneal irritation-induced visceral pain and to examine the effect of gabapentin on spinal cord amino acid release.Forty-eight SD rats randomly received intraperitoneal (i.p.) injection of saline or gabapentin (50, 100, or 200 mg.kg-1), and 40 minutes later, 0.6% acetic acid (4 ml.kg-1) was administrated intraperitoneally. The acetic acid-induced writhing assay was used to determine the degree of nociception. The beam balance task was employed to test a possible inhibitory or sedative effect of the central nervous system. Cerebrospinal fluid dialysate was collected by microdialysis from the spinal subarachnoid space in anesthetized rats. Concentrations of amin...
The mammalian central nervous system maintains a delicate balance between neuronal excitation and in...
Gabapentin is a well-established anticonvulsant drug which is also effective for the treatment of ne...
publisher学位の種類:医学 学位授与年月日:平成23年6月15日 主査:中尾, 慎一 教授 報告番号:甲第号 学内授与番号:医第1067号 NDL書誌ID:02351166
Background: Gabapentin has recently been used clinically as an antihyperalgesic agent to treat certa...
Aim: This study evaluates the contribution of inhibitory pain pathways that descend to the spinal co...
publisher[Abstract] Gabapentin has been proposed as one of several first-line agents to treat neurop...
Background: The mechanisms underlying neuropathic pain are complex and remain controversial. From th...
<div><p>Currently, the clinical management of visceral pain remains unsatisfactory for many patients...
We have examined the effects of a novel GABA(B) agonist, CGP35024, in models of chronic neuropathic ...
Objective To evaluate the analgesic effect of intrathecal gabapentin therapy on secondary hyperalges...
To gain insight into the mechanism of action of the anti-epileptic, gabapentin, the effects of gabap...
Abstract. Gabapentin, a γ-aminobutyric acid (GABA) analogue anticonvulsant, is also an effective ana...
AbstractAimThis study evaluates the contribution of inhibitory pain pathways that descend to the spi...
Although gabapentin (GBP) is a first-line treatment in the management of neuropathic pain, its mecha...
Pregabalin and gabapentin are amino-acid derivatives of gamma-aminobutyric acid. They have a high af...
The mammalian central nervous system maintains a delicate balance between neuronal excitation and in...
Gabapentin is a well-established anticonvulsant drug which is also effective for the treatment of ne...
publisher学位の種類:医学 学位授与年月日:平成23年6月15日 主査:中尾, 慎一 教授 報告番号:甲第号 学内授与番号:医第1067号 NDL書誌ID:02351166
Background: Gabapentin has recently been used clinically as an antihyperalgesic agent to treat certa...
Aim: This study evaluates the contribution of inhibitory pain pathways that descend to the spinal co...
publisher[Abstract] Gabapentin has been proposed as one of several first-line agents to treat neurop...
Background: The mechanisms underlying neuropathic pain are complex and remain controversial. From th...
<div><p>Currently, the clinical management of visceral pain remains unsatisfactory for many patients...
We have examined the effects of a novel GABA(B) agonist, CGP35024, in models of chronic neuropathic ...
Objective To evaluate the analgesic effect of intrathecal gabapentin therapy on secondary hyperalges...
To gain insight into the mechanism of action of the anti-epileptic, gabapentin, the effects of gabap...
Abstract. Gabapentin, a γ-aminobutyric acid (GABA) analogue anticonvulsant, is also an effective ana...
AbstractAimThis study evaluates the contribution of inhibitory pain pathways that descend to the spi...
Although gabapentin (GBP) is a first-line treatment in the management of neuropathic pain, its mecha...
Pregabalin and gabapentin are amino-acid derivatives of gamma-aminobutyric acid. They have a high af...
The mammalian central nervous system maintains a delicate balance between neuronal excitation and in...
Gabapentin is a well-established anticonvulsant drug which is also effective for the treatment of ne...
publisher学位の種類:医学 学位授与年月日:平成23年6月15日 主査:中尾, 慎一 教授 報告番号:甲第号 学内授与番号:医第1067号 NDL書誌ID:02351166