The clinical implication of SS18-SSX fusion gene in synovial sarcoma
- Ren, T.
- Lu, Q.
- Guo, W.
- Lou, Z.
- Peng, X.
- Jiao, G.
- Sun, Y.
DOIAbstract
Background: The aim of this study is to evaluate distribution and clinical impact of the SS18-SSX fusion gene in patients with synovial sarcoma in China. Methods: We collected and analysed the clinical data of 88 patients using univariate and multivariate survival analysis. HEK 293T and NIH 3T3 cell lines were transfected with the SS18-SSX1 or SS18-SSX2 gene to determine the respective involvement of these fusion genes in cell proliferation and invasion. Results: Overall survival was significantly better among SS18-SSX2 cases (P = 0.001), FNCLCC grade 2 cases (P<0.001), and UICC stage 1 or 2 (P<0.001) by univariate and multivariate survival analysis. SS18-SSX1-positive cells were more proliferative and invasive than SS18-SSX2-po...
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