By means of an ESR spin-trapping method, we have shown that A beta (amyloid beta), alpha-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation
Free radicals are unstable chemical reactive species produced during Redox dyshomeostasis (RDH) insi...
There is clear evidence implicating oxidative stress in the pathology of many neurodegenerative dise...
Oxidative damages are linked to several aging-related diseases and are among the chemical pathways d...
The deposition of abnormal protein fibrils is a prominent pathological feature of many different ‘pr...
The formation of extracellular or intracellular deposits of amyloid-like protein fibrils is a promin...
There is clear evidence implicating oxidative stress in the pathology of many different neurodegener...
There is clear evidence implicating oxidative stress in the pathology of many different neurodegener...
Alzheimer disease and familial British dementia are neurodegenerative diseases that are characterize...
Using a method based on ESR spectroscopy and spin-trapping, we have shown that Abeta (amyloid beta-p...
By means of electron spin resonance spectroscopy, in conjunction with the spin trapping technique, w...
α-Synuclein is the main component of the intracellular protein aggregates in neurons of patients wit...
Two hypothesized causes of Alzheimer’s disease due to oxidative stress are progressive cerebral accu...
Hydrogen peroxide (H2O2) has long been considered a toxic byproduct of cellular metabolism and a cau...
The prion protein (PrP) has a central role in the pathogenesis of transmissible spongiform encepha-l...
Aggregation of the misfolded proteins β-amyloid, tau, huntingtin, and α-synuclein is one of the most...
Free radicals are unstable chemical reactive species produced during Redox dyshomeostasis (RDH) insi...
There is clear evidence implicating oxidative stress in the pathology of many neurodegenerative dise...
Oxidative damages are linked to several aging-related diseases and are among the chemical pathways d...
The deposition of abnormal protein fibrils is a prominent pathological feature of many different ‘pr...
The formation of extracellular or intracellular deposits of amyloid-like protein fibrils is a promin...
There is clear evidence implicating oxidative stress in the pathology of many different neurodegener...
There is clear evidence implicating oxidative stress in the pathology of many different neurodegener...
Alzheimer disease and familial British dementia are neurodegenerative diseases that are characterize...
Using a method based on ESR spectroscopy and spin-trapping, we have shown that Abeta (amyloid beta-p...
By means of electron spin resonance spectroscopy, in conjunction with the spin trapping technique, w...
α-Synuclein is the main component of the intracellular protein aggregates in neurons of patients wit...
Two hypothesized causes of Alzheimer’s disease due to oxidative stress are progressive cerebral accu...
Hydrogen peroxide (H2O2) has long been considered a toxic byproduct of cellular metabolism and a cau...
The prion protein (PrP) has a central role in the pathogenesis of transmissible spongiform encepha-l...
Aggregation of the misfolded proteins β-amyloid, tau, huntingtin, and α-synuclein is one of the most...
Free radicals are unstable chemical reactive species produced during Redox dyshomeostasis (RDH) insi...
There is clear evidence implicating oxidative stress in the pathology of many neurodegenerative dise...
Oxidative damages are linked to several aging-related diseases and are among the chemical pathways d...