Amyloid deposits derived from the amylin peptide accumulate within pancreatic islet P-cells in most cases of type-2 diabetes mellitus (T2Dm). Human amylin 'oligomers' are toxic to these cells. Using two different experimental techniques, we found that H2O2 was generated during the aggregation of human amylin into amyloid fibrils. This process was greatly stimulated by Cu(II) ions, and human amylin was retained on a copper affinity column. In contrast, rodent amylin, which is not toxic, failed to generate any H2O2 and did not interact with copper. We conclude that the formation Of H202 from amylin could contribute to the progressive degeneration of islet cells in T213m. (c) 2007 Federation of European Biochemical Societies. Published by Else...
Type 2 diabetes (T2D) is one of the most common chronic diseases, affecting over 300 million people ...
Amylin, a pancreatic β-cell hormone, was the focus of this research project. This hormone is co-loca...
Hye Rin Jeong, Seong Soo A AnDepartment of Bionano Technology, Gachon Medical Research Institute, Ga...
AbstractAmyloid deposits derived from the amylin peptide accumulate within pancreatic islet β-cells ...
Human amylin (hA), which is toxic to islet β-cells, can self-generate H(2)O(2), and this process is ...
Type 2 diabetes mellitus (T2Dm) is characterized by reduced β cell mass and amyloid deposits of huma...
Type-2 diabetes (T2D) is considered to be a potential threat on a global level. Recently, T2D has be...
Amylin amyloid deposition is a common feature in the pancreas of type-2 diabetic (T2D) patients, and...
Amylin is the 37-residue peptide hormone produced by the islet β-cells in the pancreas and the forma...
Amylin is the 37-residue peptide hormone produced by the islet β-cells in the pancreas and the forma...
Human islet amyloid polypeptide (hIAPP) is the major component of amyloid deposits found in pancreat...
Amyloidosis is a common pathological event in which proteins self-assemble into misfolded soluble an...
In recent decades, type 2 diabetes complications have been correlated with amylin aggregation, coppe...
Amyloidosis is a clinical disorder implicated with the formation of toxic amyloid aggregates. Despit...
AbstractIslet amyloid polypeptide (IAPP, amylin) is secreted from pancreatic islet β-cells and conve...
Type 2 diabetes (T2D) is one of the most common chronic diseases, affecting over 300 million people ...
Amylin, a pancreatic β-cell hormone, was the focus of this research project. This hormone is co-loca...
Hye Rin Jeong, Seong Soo A AnDepartment of Bionano Technology, Gachon Medical Research Institute, Ga...
AbstractAmyloid deposits derived from the amylin peptide accumulate within pancreatic islet β-cells ...
Human amylin (hA), which is toxic to islet β-cells, can self-generate H(2)O(2), and this process is ...
Type 2 diabetes mellitus (T2Dm) is characterized by reduced β cell mass and amyloid deposits of huma...
Type-2 diabetes (T2D) is considered to be a potential threat on a global level. Recently, T2D has be...
Amylin amyloid deposition is a common feature in the pancreas of type-2 diabetic (T2D) patients, and...
Amylin is the 37-residue peptide hormone produced by the islet β-cells in the pancreas and the forma...
Amylin is the 37-residue peptide hormone produced by the islet β-cells in the pancreas and the forma...
Human islet amyloid polypeptide (hIAPP) is the major component of amyloid deposits found in pancreat...
Amyloidosis is a common pathological event in which proteins self-assemble into misfolded soluble an...
In recent decades, type 2 diabetes complications have been correlated with amylin aggregation, coppe...
Amyloidosis is a clinical disorder implicated with the formation of toxic amyloid aggregates. Despit...
AbstractIslet amyloid polypeptide (IAPP, amylin) is secreted from pancreatic islet β-cells and conve...
Type 2 diabetes (T2D) is one of the most common chronic diseases, affecting over 300 million people ...
Amylin, a pancreatic β-cell hormone, was the focus of this research project. This hormone is co-loca...
Hye Rin Jeong, Seong Soo A AnDepartment of Bionano Technology, Gachon Medical Research Institute, Ga...