Effect of Iodinated Contrast Media on Renal Function Evaluated with Dynamic Three-dimensional MR Renography

Purpose: To assess the hemodynamic effect of iodinated contrast media (CM) on glomerular filtration rate (GFR) by using dynamic three-dimensional magnetic resonance (MR) renography in a rabbit model. Materials and Methods: This study was approved by the university animal care and use committee. Twelve healthy male New Zealand rabbits (body mass range, 2.5-3.0 kg) were included. Two of them were sacrificed before MR examination to obtain renal histologic samples as controls. The other ten rabbits completed 4-minute dynamic contrast material-enhanced MR imaging 24 hours before and 20 minutes after intravenous injection of iopamidol (370 mg of iodine per milliliter) at a dose of 6 mL per kilogram of body weight. Blood volume (V-B), GFR, and tubule volume (V-E) of the renal cortex were determined with a two-compartment kinetic model. Maximum upslope (K-m), peak concentration (P-c), and initial 60-second area under the curve (IAUC) of the whole kidney renogram curve were measured with semiquantitative analysis. The self-control data were compared by using the Student paired t test. Results: Iopamidol significantly decreased cortical V-B (mean, 42.53% +/- 10.16 [standard deviation] before CM administration vs 27.23% +/- 16.13 after CM administration; P < .01), V E (mean, 22.40% +/- 11.69 before CM administration vs 11.51% 6 6.58 after CM administration; P < .01), and GFR (mean, 31.92 mL/100 g per minute +/- 12.52 before CM administration vs 21.48 mL/100 g per minute 6 10.02 after CM administration; P < .01). Results of whole-kidney renogram analysis showed a decrease in K-m, P-c, and IAUC caused by iopamidol administration. Conclusion: High-dose iopamidol resulted in a marked decrease in renal function, which could be detected at dynamic three-dimensional MR renography.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335135300012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Radiology, Nuclear Medicine & Medical ImagingSCI(E)PubMed8ARTICLEwangxiaoy-ing@vip.163.com2409-41527