Intrinsic noise analysis and stochastic simulation on transforming growth factor beta signal pathway
- Wang Lu
- Ouyang Qi
DOIAbstract
A typical biological cell lives in a small volume at room temperature; the noise effect on the cell signal transduction pathway may play an important role in its dynamics. Here, using the transforming growth factor-beta signal transduction pathway as an example, we report our stochastic simulations of the dynamics of the pathway and introduce a linear noise approximation method to calculate the transient intrinsic noise of pathway components. We compare the numerical solutions of the linear noise approximation with the statistic results of chemical Langevin equations, and find that they are quantitatively in agreement with the other. When transforming growth factor-beta dose decreases to a low level, the time evolution of noise fluctuation ...
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