Dynamic properties of cell-cycle and life-cycle networks in budding yeast

Dynamic behaviors of protein-protein and protein-DNA interactions in living cells are investigated using the cell-cycle network and life-cycle network in budding yeast as model systems. Our analysis reveals important dynamic properties of the biological networks. In phase space, the resting states of the networks are global attractors, almost all initial protein states evolve to these stationary states, the biological pathways toward the stationary state are globally attracting trajectories. All initial states are through these well-defined sequences. The distributions of attractor size and pathway thickness of biological network are distinct from that of random networks. Perturbation analysis shows that these networks are dynamically stable. These results suggest that protein networks are robustly designed for their functions, and that the global dynamic properties of protein networks are intimately coupled to their functions.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000248441100010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701BiophysicsMathematical & Computational BiologyCPCI-S(ISTP)