A plasma separation device based on centrifugal effect and Zweifach-Fung effect

A microfluidic chip used in separation of plasma from whole blood, which combines, the Zweifach-Fung bifurcation law, centrifugation and diffuser-nozzle effect, is presented. The characteristics of this device were investigated at different flow rates. The efficiency of plasma separation in this divice reached more than 95 percent at a flow rate 0.0628??l/s. The simple planar structure and high throughput offered by this passive microfluidic approach make it attractive for clinical application and integration with microfluidic chip. Copyright ? (2011) by the Chemical and Biological Microsystems Society.EI