Impact of early catheterization laboratory activation on door-to-balloon time in patients with ST-segment elevation acute myocardial infarction

目的 探讨依据院前心电图和电话通知的导管室启动模式能否缩短ST段抬高心肌梗死患者进门至球囊扩张时间.方法 收集2006年1月至2008年12月期间就诊于北京安贞医院抢救中心并接受直接经皮冠状动脉介入的ST段抬高心肌梗死患者的临床资料.按不同导管室启动模式,即是否有院前心电图及院前电话,将患者分为3组:A组(无院前心电图)、B组(有院前心电图)和C组(根据院前心电图进行院前电话通知).主要分析指标为进门至球囊扩张时间.次要分析指标为临床终点,包括肌钙蛋白I峰值、左心室射血分数、住院天数、院内病死率及随访30 d病死率.结果 共入选患者506例,A、B和C组患者分别为168例、224例和114例.3组患者基础临床资料差异无统计学意义.与A组比较,B组和C组进门至球囊扩张时间显著缩短(110 min比94 min和85min,P均<0.01),B组与C组差异也有统计学意义(P<0.05).与A组比较,B组和C组进门至进导管室时间缩短(91 min比74 min和64 min,P均<0.01),B组与C组差异也有统计学意义(P<0.05).进门至球囊扩张时间小于90 min的比例C组显著高于B组和A组(59%比43%和32%,P均<0.01).结论 依据院前心电图和早期电话通知启动介入治疗显著缩短ST段抬高心肌梗死患者导管室启动和进门至球囊扩张时间,并使更多的患者进门至球囊扩张时间小于90 min.Objective To determine whether early catheterization laboratory activation would reduce median door-to-balloon time in patients with ST elevation myocardial infarction (STEMI) . Methods Consecutive patients with STEMI underwent primary percutaneous coronary intervention (PCI) from January 2006 to December 2008 in Beijing Anzhen Hospital were analyzed. Patients were divided into three groups. Group A included patients without prehospital ECG (n = 168) , group B included patients with prehospital ECG (n = 224) and group C included patients with prehospital ECG and early telephonic notification to activate catheterization laboratory (n = 114). Primary end point was door-to-balloon time, secondary end points included peak Troponin I elevation, left ventricular ejection fraction, length of hospital stay, hospital mortality and 30 days follow-up mortality. Results Baseline characteristics were similar among groups. Door-to-balloon time and door-to-catheter laboratory time (110 minutes, 94 minutes and 85 minutes, respectively, all P <0. 01; 91 minutes, 74 minutes and 64 minutes, respectively, all P < 0. 01) were significantly shorter in group B and C than those in group A. The percentage of patients with door-to-balloon time less than 90 minutes increased significantly from 32% in group A to 43% in group B and 59% in group C ( P < 0. 01). Conclusion Early activation of catheterization laboratory by prehospital ECG and telephonic notification could markedly reduce door-to-balloon time in patients with STEMI.北京市科委基金中文核心期刊要目总览(PKU)中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)07625-6283