Effects of Fosinopril vs Amlodipine on brachial ankle pulse wave velocity and pulse pressure in patients of primary hypertension

2003年至2006年在我院门诊、住院及所管辖社区的560例原发性高血压患者分为2组:福辛普利组260例(10～20 mg,1次/d),苯磺酸氨氯地平组300例(5～10 mg,1次/d),2组疗程均为12个月.分别在给药前及给药后6个月、12个月采用VP-1000全自动动脉硬化检测仪进行四肢血压、脉搏波速度(baPWV)的检查.结果 示服药后福辛普利组平均血压(136/85 mm Hg,1 mm Hg=0.133 kPa)高于苯磺酸氨氯地平组(132/76 mm Hg);福辛普利组平均baPWV(1310 cm/s)小于苯磺酸氨氯地平组(1400 cm1/s);福辛普利组平均咏压、(52 mm Hg)小于苯磺酸氨氯地平组(56 mm Hg).均P＜0.01.提示苯磺酸氨氯地平降压幅度大于福辛普利,福辛普利对大动脉弹性的改善强于苯磺酸氨氯地平.A total of 560 patients with primary hypertension were divided into two groups.Of them,260 were treated with Fosinopril(10～20 mg once daily),and the other 300 were treated with Amlodipine (5～10 mg once daily).The treatment lasted for 12 months in both groups.The levels of blood pressure (BP)、braehial ankle pulse wave velocity(baPWV)and pulse pressure(PP)were examined at baseline,6 month and 12 month with automatic analysis system of arteriosclerosis.BP in Amlodipine group(132/76 mm Hg)decreased more significantly than Fosinopril group(136/85 mm Hg),but Fosinopril group showed more remarkable changes in baPWV(1310 cm/s)and PP(52 mm Hg)than Amlodipine group(1400 cm/s and 56 mm Hg).中国科技核心期刊(ISTIC)04268-270