Mineralogy of psammoma bodies in two types of ovarian tumors

砂粒体是病理诊断中常见的钙化形式,与肿瘤关系密切.选取具有砂粒体矿化物的6例卵巢浆液癌和2例成熟性囊性畸胎瘤样品,采用POM、ESEM、EDX、TEM、μ-SRXRD和μ-SRXRF等研究方法,对原位和分离处理后的砂粒体进行了观察测试.结果表明,两种卵巢肿瘤中的砂粒体由粒状和短柱状矿物分层集合而成,其形成与胶原纤维关系密切.卵巢浆液癌和畸胎瘤中的砂粒体最大直径分别为35 μm、70μm,主要矿物成分分别为碳羟磷灰石Ca5[PO4,CO3]3 (OH)、羟基磷灰石Ca5 (PO4)3 (OH).砂粒体中还含有Na、Mg、Zn、Fe、Sr、Cu等微量元素,Zn可替代Ca进入矿物晶格.Psammoma body is a common form of calcification in pathological diagnosis and has close relevance to tumors. This paper focuses on mineralization in two types of ovarian tumors, ovarian serous cancer (6 cases) and teratoma (2 cases), using mineralogical research methods, such as POM, ESEM, EDX, TEM, ??-SRXRD and ??-SRXRF to investigate the psammoma bodies both in the tissue and separated. The results show that psammoma body consists of round and short column minerals which assembled lamellately. Its formation is closely related to collagenous fibers. In ovarian serous cancer and teratoma, the maximum diameters of the psammoma bodies are 35 ??m and 70 ??m respectively, and the main mineral compositions are carbonate hydroxyapatite (Ca5[PO4, CO3]3 (OH)) and hydroxyapatite (Ca5(PO4)3 (OH)) respectively. There is also Na, Mg, Zn, Fe, Sr, Cu and other elements in psammoma bodies. Zn can take place of Ca in the crystal lattices.国家自然科学基金项目EI中文核心期刊要目总览(PKU)中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)03154-1602