Publication date
January 2002
DOI Publisher
中国癌症杂志 Journal
issn:1007-3639Abstract
泛素-蛋白酶体途径是调节多种细胞生物学过程的重要机制,也是恶性肿瘤相关调节异常的潜在靶点;这种途径通过其特殊的蛋白酶体裂解活性,可上调或下调某些抑癌基因、转录因子和细胞周期素等的表达以及改变MHC-Ⅰ限制性抗原肽的生成,从而参与恶性肿瘤的发生和发展.0174-76,961
泛素-蛋白酶体途径是调节多种细胞生物学过程的重要机制,也是恶性肿瘤相关调节异常的潜在靶点;这种途径通过其特殊的蛋白酶体裂解活性,可上调或下调某些抑癌基因、转录因子和细胞周期素等的表达以及改变MHC-Ⅰ限制性抗原肽的生成,从而参与恶性肿瘤的发生和发展.0174-76,961
Deep insight on Ubiquitin, ubiquitination and the ubiquitin-proteasome system in cancer
Contains fulltext : 51123.pdf (publisher's version ) (Closed access)The modificati...
The ubiquitin proteasome system is involved in a myriad of biological functions including cell cycle...
肿瘤多药耐药是肿瘤治愈的主要障碍之一.肿瘤细胞对抗癌药物诱导的凋亡的耐受是多药耐药形成的重要原因.蛋白酶体抑制剂可选择性地促进肿瘤细胞凋亡,逆转多药耐药.蛋白酶体被认为是肿瘤治疗的新靶点.国家高技术研...
The ubiquitin proteasome pathway is the most significant intracellular proteolytic pathway. The targ...
The ubiquitin (Ub)-proteasome pathway is the major non-lysosomal pathway of proteolysis in human cel...
Background: The ubiquitin-proteasome pathway is crucial for all cellular processes and is, therefore...
作为体内蛋白质降解的途径之一,蛋白酶体具有非常重要的生理作用,并与多种疾病密切相关.抑制蛋白酶体的功能已经成为肿瘤治疗的又一有前景的新途径,并受到越来越多的关注.本文对蛋白酶体的组成结构、病理生理作用...
The ubiquitin/proteasome pathway is highly conserved in evolution and is essential for many diverse ...
The ubiquitin proteasome system (UPS) is the main cellular degradation machinery designed for contro...
作为基因组研究的延伸,蛋白质组学已成为世界生命科学领域的一个极其活跃的部分,是功能基因组时代或后基因组时代的核心.近年来发展起来的几种蛋白质组学新技术克服了传统蛋白质组学技术的不足,有力推进了肿瘤标志...
Summary: The Ubiquitin-Proteasome System (UPS) is the primary route for selective protein degradatio...
The proteasome is a multicatalytic protease and the principal non-lysosomal proteolytic system in al...
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109768/1/imr12236.pd
T细胞免疫需要双信号系统进行活化,其中B7/CD28分子介导的协同刺激信号发挥了必不可少的作用.目前已发现10个B7家族成员[1-2](表1).B7分子在淋巴和非淋巴器官均有表达,不同成员与相应受体结...
Deep insight on Ubiquitin, ubiquitination and the ubiquitin-proteasome system in cancer
Contains fulltext : 51123.pdf (publisher's version ) (Closed access)The modificati...
The ubiquitin proteasome system is involved in a myriad of biological functions including cell cycle...
肿瘤多药耐药是肿瘤治愈的主要障碍之一.肿瘤细胞对抗癌药物诱导的凋亡的耐受是多药耐药形成的重要原因.蛋白酶体抑制剂可选择性地促进肿瘤细胞凋亡,逆转多药耐药.蛋白酶体被认为是肿瘤治疗的新靶点.国家高技术研...
The ubiquitin proteasome pathway is the most significant intracellular proteolytic pathway. The targ...
The ubiquitin (Ub)-proteasome pathway is the major non-lysosomal pathway of proteolysis in human cel...
Background: The ubiquitin-proteasome pathway is crucial for all cellular processes and is, therefore...
作为体内蛋白质降解的途径之一,蛋白酶体具有非常重要的生理作用,并与多种疾病密切相关.抑制蛋白酶体的功能已经成为肿瘤治疗的又一有前景的新途径,并受到越来越多的关注.本文对蛋白酶体的组成结构、病理生理作用...
The ubiquitin/proteasome pathway is highly conserved in evolution and is essential for many diverse ...
The ubiquitin proteasome system (UPS) is the main cellular degradation machinery designed for contro...
作为基因组研究的延伸,蛋白质组学已成为世界生命科学领域的一个极其活跃的部分,是功能基因组时代或后基因组时代的核心.近年来发展起来的几种蛋白质组学新技术克服了传统蛋白质组学技术的不足,有力推进了肿瘤标志...
Summary: The Ubiquitin-Proteasome System (UPS) is the primary route for selective protein degradatio...
The proteasome is a multicatalytic protease and the principal non-lysosomal proteolytic system in al...
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109768/1/imr12236.pd
T细胞免疫需要双信号系统进行活化,其中B7/CD28分子介导的协同刺激信号发挥了必不可少的作用.目前已发现10个B7家族成员[1-2](表1).B7分子在淋巴和非淋巴器官均有表达,不同成员与相应受体结...
Deep insight on Ubiquitin, ubiquitination and the ubiquitin-proteasome system in cancer
Contains fulltext : 51123.pdf (publisher's version ) (Closed access)The modificati...
The ubiquitin proteasome system is involved in a myriad of biological functions including cell cycle...
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