The Charge Transfer Reaction between Chlorpheniraminum and 7,7,8,8-Tetracyanoquinodemethane

以马来酸氯本那敏(商品名扑尔敏)作为电荷给体,7,7,8,8-四氰基对二次甲基苯醌(TCNQ)作为电子受体,研究了它们之间形成电荷转移络合物的最佳条件.结果表明:在丙酮介质中,二者于室温(20℃)下30 min即可形成1∶2络合物,室温下至少稳定2h.络合物的最大吸收波长为845 nm.表观摩尔吸光系数ε为4.63×104 L*mol-1*cm-1,在0～6 mg/L范围内符合比尔定律.方法的相对标准偏差为1.2%(n=10).对形成荷移络合物的机理进行了探讨;用拟定的方法对片剂样品中马来酸氯本那敏的含量进行了测定,结果与药典方法一致,回收率符合要求.A spectrophotometric method for the determination of chlorpheniraminum has been developed based on the charge transfer (CT) reaction. The reaction between chlorpheniraminum and 7,7,8,8-tetracyanoquinodemethane (TCNQ) was completed in acetone medium within 30 min at room temperature. The charge transfer complex is stable at least 2 h. Beer's law is obeyed in the range of 0 similar to 6 mg/L of chlorpheniraminum. The, molar absorptivity of the complex at 845 nm was 4.63 x 10(4) L.mol(-1).cm(-1). The relative standard deviation was 1.2% (n = 10). The composition of the complex was found to be 1:2 by slope ratio and Bent-French methods. The mechanism, of reaction was investigated. The method has been applied to the determination of chlorpheniraminum in tablet with satisfactory results.国家自然科学基金SCI(E)中文核心期刊要目总览(PKU)中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)1111327-13293