目的:探讨褪黑素对吗啡依赖小鼠肝组织损害的治疗作用.方法:用皮下定量注射吗啡的方法建立吗啡依赖小鼠模型,经褪黑素治疗4周后,用HE染色、酶组织化学染色及图像分析方法,在光镜下观察吗啡依赖小鼠肝脏组织结构及酶组织化学变化.结果:肝细胞变性的发生率在吗啡自然戒断组为10例(10/10);ACP、LDH活性升高,而SDH活性降低.褪黑素治疗组仅1例(1/10),且为个别肝细胞水肿;ACP、LDH和SDH活性正常.结论:褪黑素可使吗啡所致的肝损害得到良好恢复.中国科学引文数据库(CSCD)04264-2671
<p>Mice were treated as Materials and Methods. Liver samples were collected at 4 h after APAP admini...
<p>Mice were treated as Materials and Methods. Liver samples were collected at 4 h after APAP admini...
<p>Mice were treated as Materials and Methods. Liver samples were collected at 4 h after APAP admini...
目的观察褪黑激素对吗啡依赖小鼠肝组织损害的作用.方法利用皮下定量注射吗啡的方法建立吗啡依赖小鼠模型,并在光镜下观察经褪黑激素治疗4wk后吗啡依赖小鼠肝脏病理学变化.结果肝细胞变性的发生率在吗啡自然戒断...
目的探讨褪黑素(MT)对吗啡依赖小鼠免疫功能的影响及其与一氧化氮(NO)的关系.方法 sc吗啡建立小鼠身体依赖模型;纳洛酮催瘾;称量免疫器官重量;Con A刺激的脾细胞淋巴增殖反应;碳粒廓清实验检测小...
目的探讨褪黑素对吗啡依赖小鼠肾组织损害的治疗作用。方法用皮下定量注射吗啡的方法建立吗啡依赖小鼠模型，经褪黑素治疗 4周后，用 HE染色、酶组织化学染色及图像分析方法，在光镜下观察吗啡依赖小鼠肾脏组织结...
目的观察褪黑素(melatonin,MT)对吗啡戒断小鼠学习记忆能力及海马CAI区细胞数的影响并探讨其机制.方法建立小鼠吗啡依赖模型,皮下注射定量吗啡,在注射吗啡的同时每天2次(早晚8:00)用不同剂...
目的:探讨褪黑素(melatonin,MT)抑制吗啡戒断反应的作用及其与脑脊液(CSF)和血浆中cAMP含量的关系.方法:建立吗啡依赖大鼠自然戒断模型,脑室插管及放免测定吗啡依赖大鼠CSF和血浆中cA...
目的:探讨β-内啡肽(β-endorphin,β-EP)在褪黑素(melatonin,MT)缓解大鼠吗啡戒断反应中的作用.方法:建立急性吗啡依赖大鼠及吗啡自然戒断模型,用脑室插管进行推挽灌流及侧脑室微...
<p>Mice were treated as Materials and Methods. Liver samples were collected at 4 h after APAP. The e...
探讨了褪黑素(MT)神经保护作用的机理. 采用大鼠&quot;四动脉结扎法&quot;制成全脑缺血(20 min)-再灌注模型. ①于再灌注开始时ip MT 2.5或10 mg*kg-...
目的:观察褪黑素（melatonin,MT）对吗啡戒断小鼠前列腺及睾丸的组织学影响。方法：设立对照组（A）和实验组（B、C、D），实验组分别皮下注射定量吗啡，建立吗啡依赖模型，A组皮下注射等量生理盐水...
The effect of melatonin was examined on carbon tetrachloride (CCl_4)-induced liver injury in mouse. ...
为了阐明褪黑素对免疫功能的调节作用,本文利用束缚应激模型,观察褪黑素在整体和离体水平是否能够对抗应激血清抑制正常淋巴细胞转化的活性.结果表明,腹腔注射褪黑素12.5～50.0 mg/kg,能够剂量依赖...
目的 探讨褪黑素对全肝缺血再灌注大鼠肺组织细胞凋亡的影响作用及相关机制.方法 30只SD大鼠随机分3组:褪黑素治疗组,缺血再灌注组与假手术对照组.阻断肝门30 min后开放血流,建立大鼠全肝缺血再灌注...
<p>Mice were treated as Materials and Methods. Liver samples were collected at 4 h after APAP admini...
<p>Mice were treated as Materials and Methods. Liver samples were collected at 4 h after APAP admini...
<p>Mice were treated as Materials and Methods. Liver samples were collected at 4 h after APAP admini...
目的观察褪黑激素对吗啡依赖小鼠肝组织损害的作用.方法利用皮下定量注射吗啡的方法建立吗啡依赖小鼠模型,并在光镜下观察经褪黑激素治疗4wk后吗啡依赖小鼠肝脏病理学变化.结果肝细胞变性的发生率在吗啡自然戒断...
目的探讨褪黑素(MT)对吗啡依赖小鼠免疫功能的影响及其与一氧化氮(NO)的关系.方法 sc吗啡建立小鼠身体依赖模型;纳洛酮催瘾;称量免疫器官重量;Con A刺激的脾细胞淋巴增殖反应;碳粒廓清实验检测小...
目的探讨褪黑素对吗啡依赖小鼠肾组织损害的治疗作用。方法用皮下定量注射吗啡的方法建立吗啡依赖小鼠模型，经褪黑素治疗 4周后，用 HE染色、酶组织化学染色及图像分析方法，在光镜下观察吗啡依赖小鼠肾脏组织结...
目的观察褪黑素(melatonin,MT)对吗啡戒断小鼠学习记忆能力及海马CAI区细胞数的影响并探讨其机制.方法建立小鼠吗啡依赖模型,皮下注射定量吗啡,在注射吗啡的同时每天2次(早晚8:00)用不同剂...
目的:探讨褪黑素(melatonin,MT)抑制吗啡戒断反应的作用及其与脑脊液(CSF)和血浆中cAMP含量的关系.方法:建立吗啡依赖大鼠自然戒断模型,脑室插管及放免测定吗啡依赖大鼠CSF和血浆中cA...
目的:探讨β-内啡肽(β-endorphin,β-EP)在褪黑素(melatonin,MT)缓解大鼠吗啡戒断反应中的作用.方法:建立急性吗啡依赖大鼠及吗啡自然戒断模型,用脑室插管进行推挽灌流及侧脑室微...
<p>Mice were treated as Materials and Methods. Liver samples were collected at 4 h after APAP. The e...
探讨了褪黑素(MT)神经保护作用的机理. 采用大鼠&quot;四动脉结扎法&quot;制成全脑缺血(20 min)-再灌注模型. ①于再灌注开始时ip MT 2.5或10 mg*kg-...
目的:观察褪黑素（melatonin,MT）对吗啡戒断小鼠前列腺及睾丸的组织学影响。方法：设立对照组（A）和实验组（B、C、D），实验组分别皮下注射定量吗啡，建立吗啡依赖模型，A组皮下注射等量生理盐水...
The effect of melatonin was examined on carbon tetrachloride (CCl_4)-induced liver injury in mouse. ...
为了阐明褪黑素对免疫功能的调节作用,本文利用束缚应激模型,观察褪黑素在整体和离体水平是否能够对抗应激血清抑制正常淋巴细胞转化的活性.结果表明,腹腔注射褪黑素12.5～50.0 mg/kg,能够剂量依赖...
目的 探讨褪黑素对全肝缺血再灌注大鼠肺组织细胞凋亡的影响作用及相关机制.方法 30只SD大鼠随机分3组:褪黑素治疗组,缺血再灌注组与假手术对照组.阻断肝门30 min后开放血流,建立大鼠全肝缺血再灌注...
<p>Mice were treated as Materials and Methods. Liver samples were collected at 4 h after APAP admini...
<p>Mice were treated as Materials and Methods. Liver samples were collected at 4 h after APAP admini...
<p>Mice were treated as Materials and Methods. Liver samples were collected at 4 h after APAP admini...
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