A pair of isomeric saponins with cytotoxicity from Albizzia julibrissin

Two new saponins have been isolated from the stem barks of Albizzia julibrissin Durazz, and their structures identified as 3-O-[beta-d-xylopyranosyl-(1 -> 2)-beta-d-fucopyranosyl-(1 -> 6)-beta-d-2-deoxy-2-acetoamidoglucopyranosyl]-21-O-{(6S)-2-trans-2-hydroxymethyl-6-methyl-6- O-[4-O-((6S)-2-trans-2-hydroxymethyl-6-hydroxy-6-methyl-2,7-octadienoyl)-beta-d-quinovopyranosyl]-2,7-octadienoyl}-acacic acid-28-O-beta-d-glucopyranosyl-(1 -> 3)-[alpha-l-arabinofuranosyl-(1 -> 4)]-alpha-l-rhamnopyranosyl-(1 -> 2)-beta-d-glucopyranosyl ester (1) and 3-O-[beta-d-xylopyranosyl-(1 -> 2)-beta-d-fucopyranosyl-(1 -> 6)-beta-d-2-deoxy-2-acetoamidoglucopyranosyl]-21-O-{(6S)-2-trans-2-hydroxymethyl-6-methyl-6- O-[3-O-((6S)-2-trans-2-hydroxymethyl-6-hydroxy-6-methyl-2,7-octadienoyl)-beta-d-quinovopyranosyl]-2,7-octadienoyl}acacic acid 28-O-beta-d-glucopyranosyl-(1 -> 3)-[alpha-l-arabinofuranosyl-(1 -> 4)]-alpha-l-rhamnopyranosyl-(1 -> 2)-beta-d-glucopyranosyl ester (2), based on chemical and spectral evidences, named as julibroside J 19 and julibroside J 18 , respectively. Both compounds show significant inhibition action against HeLa, Bel-7402 and MDA-MB-435 cancer cell lines in vitro .Plant SciencesChemistry, AppliedChemistry, MedicinalPharmacology & PharmacySCI(E)7ARTICLE6783-789