Stereoselective synthesis and anti-inflammatory activities of 6-and 7-membered dioxacycloalkanes

A class of 5-trifluoroacetylamino-1,3-dioxacycloalkanes, 5-benzoylamino-1,3-dioxacycloalkanes and 5-amino-1,3-dioxacycloalkane compounds were stereoselectively synthesized as potential anti-inflammatory drug candidates. The anti -inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model, from which multiple compounds possessing anti-inflammatory properties which surpass aspirin were identified; these compounds were then compared to establish structure-activity relationships. (c) 2005 Elsevier Ltd. All rights reserved.Biochemistry & Molecular BiologyChemistry, MedicinalChemistry, OrganicSCI(E)0ARTICLE51339-13471