C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I

Wang, Yifan
Ng, Magdeline Tao Tao
Zhou, Tianyan
Li, Xinming
Tan, Choon Hong
Li, Tianhu

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Publication date

January 2008

DOI

10.1016/j.bmcl.2008.04.076

Publisher

生物有机化学与医药化学通讯

Journal

issn:0960-894X

Abstract

Some dumbbell-shaped circular oligonucleotides containing internal C3-spacers and Topo I-binding sites were designed and synthesized which displayed high inhibitory efficiency on the activity of human Topo I as well as resisted the degradation by some DNA repair enzymes. (C) 2008 Elsevier Ltd. All rights reserved.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000256495500029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Chemistry, MedicinalChemistry, OrganicSCI(E)5ARTICLE123597-36021

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C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I

Abstract

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C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I

Abstract

Extracted data

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