One N-confused porphyrin derivative was prepared and its first observation that it could stabilize G-quadruplex and possessed high selectivity over duplex DNA was made, furthermore, it was also proved to possess the capacity to induce a structural transition from the antiparallel to the mixed-type hybrid G-quadruplex structure. (C) 2010 Elsevier Ltd. All rights reserved.Biochemistry & Molecular BiologyChemistry, MedicinalChemistry, OrganicSCI(E)16ARTICLE31111-11161
Macrocyclic scaffolds are particularly attractive for designing selective G-quadruplex ligands essen...
Ligands that stabilize non-canonical DNA structures called G-quadruplexes (GQs) might have applicati...
Background G-quadruplex DNA structures are hypothesized to be involved in the regulation of gene exp...
The discovery of uncommon DNA structures and speculation about their potential functions in genes ha...
The discovery of uncommon DNA structures and speculation about their potential functions in genes ha...
The obtainment of tailored DNA nanostructures provided with structural and functional features usefu...
Cationic porphyrins interact strongly with guanine quadruplex DNA (G-quadruplex). We herein report t...
The interaction of the porphyrin derivative H2TCPPSpm4, having spermine pendants in the four meso po...
This thesis describes the development and synthesis of porphyrins and porphyrazines, with the potent...
The interaction of the porphyrin derivative H2TCPPSpm4, having four spermines in the meso positions,...
The G-quadruplex secondary structure has evolved as a promising anti-tumor target in recent years. T...
International audienceMacrocyclic scaffolds are particularly attractive for designing selective G-qu...
International audienceG-quadruplex DNA ligands attract much attention because of their potential use...
Background: The G-quadruplex-forming sequence within the KRAS proto-oncogene P1 promoter is a promis...
Porphyrins are heterocyclic organic molecules that can be used as highly specific fluorescent DNA pr...
Macrocyclic scaffolds are particularly attractive for designing selective G-quadruplex ligands essen...
Ligands that stabilize non-canonical DNA structures called G-quadruplexes (GQs) might have applicati...
Background G-quadruplex DNA structures are hypothesized to be involved in the regulation of gene exp...
The discovery of uncommon DNA structures and speculation about their potential functions in genes ha...
The discovery of uncommon DNA structures and speculation about their potential functions in genes ha...
The obtainment of tailored DNA nanostructures provided with structural and functional features usefu...
Cationic porphyrins interact strongly with guanine quadruplex DNA (G-quadruplex). We herein report t...
The interaction of the porphyrin derivative H2TCPPSpm4, having spermine pendants in the four meso po...
This thesis describes the development and synthesis of porphyrins and porphyrazines, with the potent...
The interaction of the porphyrin derivative H2TCPPSpm4, having four spermines in the meso positions,...
The G-quadruplex secondary structure has evolved as a promising anti-tumor target in recent years. T...
International audienceMacrocyclic scaffolds are particularly attractive for designing selective G-qu...
International audienceG-quadruplex DNA ligands attract much attention because of their potential use...
Background: The G-quadruplex-forming sequence within the KRAS proto-oncogene P1 promoter is a promis...
Porphyrins are heterocyclic organic molecules that can be used as highly specific fluorescent DNA pr...
Macrocyclic scaffolds are particularly attractive for designing selective G-quadruplex ligands essen...
Ligands that stabilize non-canonical DNA structures called G-quadruplexes (GQs) might have applicati...
Background G-quadruplex DNA structures are hypothesized to be involved in the regulation of gene exp...