Novel pH and ionic strength-sensitive vesicles composed of alkyl phosphates with 2-hydroxy-3-chloropropyl or epoxy propyl on their membrane surface

Amphiphilic alkyl (dodecyl and hexadecyl)-2-hydroxy-3-chloropropyl phosphates (C 12 - and C 16 -AHCP) were synthesized, and then alkyl glycidyl phosphates (C 12 - and C 16 -AGP) were quantitatively obtained by the treatment of AHCP with NaOH in order to prepare a novel vesicle which ...Amphiphilic alkyl (dodecyl and hexadecyl)-2-hydroxy-3-chloropropyl phosphates (C-12- and C-16-AHCP) were synthesized, and then alkyl glycidyl phosphates (C-12- and C-16-AGP) were quantitatively obtained by the treatment of AHCP with NaOH in order to prepare a novel vesicle which has reactive and polymerizable epoxy group on its membrane surface. The bilayer vesicles were formed by ultrasonication of aqueous dispersion of C-16-AHCP or C-16-AGP, but the vesicles composed of C-12-AHCP and C-12-AGP were not obtained by the same treatment. Both of C-16-AHCP and C-16-AGP bilayer vesicles are only stable at pH 5-10 or the ionic strength below 0.15. The gel-filtration chromatography and the UV-Vis absorption spectroscopic studies on Co(II) tetrakis(propyloxycarbonyl)phthalocyanine as a lipophilic probe indicated that the phthalocyanine was effectively incorporated into the C-16-AHCP bilayer membranes and predominantly present in a monomeric state in the membranes, which is much different from its leading diameric state in SDS micelle and ethanol.SCI(E)中文核心期刊要目总览(PKU)中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)104787-789+112