目的探讨妊娠期铅暴露对新生仔鼠脑组织丙二醛(MDA)、超氧化物歧化酶(SOD)的影响及对金属硫蛋白(MT)的诱导.方法采用灌胃方式于C57小鼠孕第0 d至妊娠结束进行醋酸铅染毒,仔鼠出生后第1 d处死,取脑组织测定MDA含量及SOD活性,同时测定脑组织中MT的含量.结果妊娠期铅暴露使新生仔鼠脑组织MDA及MT含量升高,SOD活性降低,均呈明显的剂量-效应关系(P＜0.01).结论铅的脑发育毒性与其引起脑组织脂质过氧化产物MDA增高及抗氧化酶SOD活性降低有关;金属铅可诱导发育中脑组织MT的产生,提示MT在体内铅的转运、代谢乃至解毒方面可能具有一定作用.中文核心期刊要目总览(PKU)0115-16,191
Background: The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of con...
Introduction: The objective of this study was to investigate the effects of lead on concentration an...
Lead (Pb) is one of the most neuro-toxic metals and its detrimental effects on early development of ...
目的探讨孕鼠铅染毒对其仔鼠脑发育及脑组织蛋白质、丙二醛(MDA)及超氧化物歧化酶(SOD)的影响.方法采用腹腔注射方式于大鼠妊娠第13、16、19天进行醋酸铅染毒,每次腹腔注射5,20,40 mg/k...
目的应用金属硫蛋白基因敲除小鼠模型,研究孕鼠铅暴露,新生仔鼠脑组织氧化损伤与金属硫蛋白(MT)间的关系.方法采用整体动物实验,于金属硫蛋白基因敲除小鼠[MT(-/-)]和野生型小鼠[MT(+/+)]孕...
目的探讨孕鼠铅染毒对仔鼠大脑皮层和海马一氧化氮(NO)含量的影响.方法采用腹腔注射方式于大鼠孕13～19 d 进行醋酸铅染毒,仔鼠出生后第一天检测大脑皮层及海马组织内蛋白质和NO含量.结果随染铅剂量的...
ABSTRACT: The course of human development from conception to adulthood is extremely complex. The dev...
Background. Low-level developmental lead exposure is linked to cognitive and neurological disorders ...
Introduction: The aims of this study were to assess the differences in the percentages of abnormal m...
Lead poisoning is a continuing crisis impacting learning, neurological and behavioral development in...
<div><p>Exposure to environmental toxicants during embryonic life causes changes in the expression o...
Introduction: The objective of this study was to investigate the effects of lead on concentration an...
目的观察和探讨铅对大鼠海马C-fos基因表达及学习记忆的影响.方法选用健康大鼠30只,每天给醋酸铅灌胃1次,高剂量组0.2 g/(kg*d),低剂量组0.1 g/(kg*d),连续染毒3个月后,用Y型...
International audienceEpidemiological studies have shown associations between prenatal exposure to l...
Epidemiological studies have shown associations between prenatal exposure to lead (Pb) and neurodeve...
Background: The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of con...
Introduction: The objective of this study was to investigate the effects of lead on concentration an...
Lead (Pb) is one of the most neuro-toxic metals and its detrimental effects on early development of ...
目的探讨孕鼠铅染毒对其仔鼠脑发育及脑组织蛋白质、丙二醛(MDA)及超氧化物歧化酶(SOD)的影响.方法采用腹腔注射方式于大鼠妊娠第13、16、19天进行醋酸铅染毒,每次腹腔注射5,20,40 mg/k...
目的应用金属硫蛋白基因敲除小鼠模型,研究孕鼠铅暴露,新生仔鼠脑组织氧化损伤与金属硫蛋白(MT)间的关系.方法采用整体动物实验,于金属硫蛋白基因敲除小鼠[MT(-/-)]和野生型小鼠[MT(+/+)]孕...
目的探讨孕鼠铅染毒对仔鼠大脑皮层和海马一氧化氮(NO)含量的影响.方法采用腹腔注射方式于大鼠孕13～19 d 进行醋酸铅染毒,仔鼠出生后第一天检测大脑皮层及海马组织内蛋白质和NO含量.结果随染铅剂量的...
ABSTRACT: The course of human development from conception to adulthood is extremely complex. The dev...
Background. Low-level developmental lead exposure is linked to cognitive and neurological disorders ...
Introduction: The aims of this study were to assess the differences in the percentages of abnormal m...
Lead poisoning is a continuing crisis impacting learning, neurological and behavioral development in...
<div><p>Exposure to environmental toxicants during embryonic life causes changes in the expression o...
Introduction: The objective of this study was to investigate the effects of lead on concentration an...
目的观察和探讨铅对大鼠海马C-fos基因表达及学习记忆的影响.方法选用健康大鼠30只,每天给醋酸铅灌胃1次,高剂量组0.2 g/(kg*d),低剂量组0.1 g/(kg*d),连续染毒3个月后,用Y型...
International audienceEpidemiological studies have shown associations between prenatal exposure to l...
Epidemiological studies have shown associations between prenatal exposure to lead (Pb) and neurodeve...
Background: The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of con...
Introduction: The objective of this study was to investigate the effects of lead on concentration an...
Lead (Pb) is one of the most neuro-toxic metals and its detrimental effects on early development of ...
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