Risk assessments of human exposure to bioaccessible phthalate esters through market fish consumption

The bioaccessibility of phthalate esters in 20 fish species collected from Hong Kong market was evaluated using an in vitro gastrointestinal model. The Sigma phthalate ester concentration detected in fresh water fish ranged from 1.66 to 3.14 mu g/g wet weight (ww) and in marine fish ranged from 1.57 to 7.10 mu g/g ww, respectively. di-2-Ethylhexyl phthalate (DEHP) and di-n-butyl phthalate (DBP) were the predominant compounds in both freshwater fish and marine fish. The digestible concentrations of phthalate esters ranged from 0.20 to 1.23 mu g/g ww (mean 0.35 mu g/g ww), and account for 2.44 to 45.5% (mean 16.8%) for raw concentrations of phthalate esters. In the present study, the accumulation ratio R-nn value of all phthalate esters was greater than 1 except for diisobutyl phthalate (DIBP), DBP and di-n-hexyl phthalate (DHP), suggesting that these phthalate esters could be accumulated during gastrointestinal digestion. Based on this health risk assessment, most of fish species were considered safe for consumption, however Hong Kong residents should take caution when consuming Mud carp and Bighead carp. (C) 2013 Elsevier Ltd. All rights reserved.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000320836900010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Environmental SciencesSCI(E)EI14ARTICLE75-8057-5