Asymmetric Catalytic 1,6-Conjugate Addition/Aromatization of para-Quinone Methides: Enantioselective Introduction of Functionalized Diarylmethine Stereogenic Centers

Chu, Wen-Dao
Zhang, Le-Fen
Bao, Xu
Zhao, Xian-He
Zeng, Chao
Du, Ji-Yuan
Zhang, Guo-Biao
Wang, Fang-Xin
Ma, Xiao-Yan
Fan, Chun-An

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Publication date

January 2013

DOI

10.1002/anie.201303928

Publisher

angewandte chemie international edition

ISSN

1433-7851

Journal

1521-3773

Citation count (estimate)

Abstract

It??s just a phase: The title reaction sequence of para-quinone methides (p-QMs) has been developed with malonates under phase-transfer catalysis. The reaction also offers an alternative route to asymmetric construction of diarylmethine stereocenters in excellent enantioselectivities and high yields. Copyright ? 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Chemistry, MultidisciplinarySCI(E)EI10ARTICLE359229-92335

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Asymmetric Catalytic 1,6-Conjugate Addition/Aromatization of para-Quinone Methides: Enantioselective Introduction of Functionalized Diarylmethine Stereogenic Centers

Abstract

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Asymmetric Catalytic 1,6-Conjugate Addition/Aromatization of para-Quinone Methides: Enantioselective Introduction of Functionalized Diarylmethine Stereogenic Centers

Abstract

Extracted data

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