Weight-neutral effect of once-daily insulin detemir in Chinese type 2 diabetes patients: Subgroup analysis of the SOLVE study

BackgroundThe present subanalysis of the Study of Once Daily Levemir (SOLVE) study was to evaluate the safety and efficacy of once-daily insulin detemir as add-on to oral antidiabetic drugs (OADs) in Chinese type 2 diabetes patients according to body mass index in a real-life setting. MethodsIn all, 3272 eligible patients who were treated with diet, exercise, and one or more OAD were prescribed once-daily insulin detemir by their physician according to routine clinical practice and were followed-up for 24 weeks. The incidence of serious adverse reactions (SADRs), including major hypoglycemia, was the primary endpoint. Subanalyses were performed on patients in the following BMI groups: normal weight (BMI<25kg/m(2)); overweight (25BMI<30kg/m(2)); and obese (BMI30kg/m(2)). ResultsNo SADRs were reported during the study. Significant improvements in glycemic levels were observed in all subgroups. For normal weight, overweight, and obese patients, the mean change in HbA1c (%/[mmol/mol]) was -1.26/-14, -1.09/-12, and -1.06/-12, respectively. The mean change in fasting plasma glucose in normal weight, overweight, and obese patients was -2.77, -2.57, and -2.71mmol/L, respectively. Slight weight gain (0.25kg), slight weight loss (-0.36kg), and weight loss (-1.32kg) were observed in the normal weight, overweight, and obese patients, respectively (P<0.001). Linear regression analysis revealed a negative relationship between weight change and baseline BMI (slope=-0.16; P<0.001). ConclusionsOnce-daily insulin detemir as add-on to OADs in Chinese patients with type 2 diabetes showed effective glycemic control and a low risk of hypoglycemia. Weight-neutral effects were observed in different BMI subgroups.Endocrinology & MetabolismSCI(E)0ARTICLEpanchy301@126.com2222-230