A versatile method for the synthesis of 3-alkoxycarbonyl beta-lactam derivatives

[GRAPHICS] Ketene-imine cvcloaddition reactions (the Staudinger reaction) of ethoxycarbonyl(phenylthio)ketene with various imines and subsequent desulfurization reactions were employed to synthesize 3-ethoxycarbonyl beta-lactam derivatives. The results indicate that the current approach provides a convenient, mild, and versatile method for synthesizing a variety of 3-alkoxycarbonyl trans-beta-lactam derivatives with good to excellent yields and diastereoselectivies.Chemistry, OrganicSCI(E)EIPubMed39ARTICLE2815-8187