Structural determination of three new germacrane-type sesquiterpene alcohols from curdione by microbial transformation

Five germacrane-type sesquiterpene alcohols obtained from curdione (1) by microbial biotransformation were isolated. Their structures were characterized as (2R)-2 beta-hydroxycurdione (2), 1 alpha, 10 beta-epoxy-11-hydroxycurdione (3), (2S)-2 alpha, 11-dihydroxycurdione (4), 11,15-dihydroxycurdione (5) and (3R)-3 alpha-hydroxycurdione (6) based on the extensive NMR studies. Among them, 4, 5 and 6 are new compounds. Copyright (C) 2006 John Wiley & Sons, Ltd.Chemistry, MultidisciplinaryChemistry, PhysicalSpectroscopySCI(E)PubMed9ARTICLE190-924