Activated microglia participate in neuroinflammation which contributes to neuronal damage in neurodegenerative diseases. Inhibition of microglial activation may have potential anti-inflammatory effects. Our laboratory has previously reported that triptolide, a natural biologically active compound extracted from Tripterygium wilfordii, could protect dopaminergic neurons from inflammation-mediated damage. However, the mechanism by which triptolide inhibits inflammation remains unknown. We reported here that inhibition of prostaglandin E-2 (PGE(2)) production could be a potential mechanism of triptolide to suppress inflammation. Triptolide suppressed c-jun NH2-terminal kinase (JNK) phosphorylation, cyclooxygenase 2 (COX-2) expression and PGE(2...
Triptolide (T10), an extract from the traditional Chinese herb, Tripterygium wilfordii Hook F (TWHF)...
Aldose reductase (AR) has a key role in several inflammatory diseases: diabetes, cancer and cardiova...
Evidence shows that an abnormal deposition of amyloid beta-peptide25-35 (Aβ25-35) was the primary ca...
Microglia are believed to participate in the mediation of neurodegeneration through producing a vari...
Mounting lines of evidence have suggested that brain inflammation participates in the pathogenesis o...
Converging lines of evidence suggest that neuroinflammatory processes may account for the progressiv...
The principal pathology of Alzheimer′s disease includes neuronal extracellular deposition of amyloid...
Evidence suggests that various forms of α-synuclein- (αSyn-) mediated microglial activation are asso...
Microglia plays an important role in mediating neuroinflammation in Alzheimer's disease (AD). I...
The complex pathogenesis of Alzheimer’s disease (AD) involves multiple contributing factors, includi...
Inhibition of dendritic cell (DC) migration into tissues and secondary lymphoid organs is an efficie...
Cuprizone (Cup) is a copper chelating agent frequently used to study factors that affect oligodendro...
Triptolide, a major bioactive ingredient of a widely used herbal medicine, has been shown to possess...
Neuropathic pain (NP) is an intractable clinical problem without satisfactory treatments. However, c...
Objective: Triptolide (TP) has been reported to suppress the expression of mitogen-activated protein...
Triptolide (T10), an extract from the traditional Chinese herb, Tripterygium wilfordii Hook F (TWHF)...
Aldose reductase (AR) has a key role in several inflammatory diseases: diabetes, cancer and cardiova...
Evidence shows that an abnormal deposition of amyloid beta-peptide25-35 (Aβ25-35) was the primary ca...
Microglia are believed to participate in the mediation of neurodegeneration through producing a vari...
Mounting lines of evidence have suggested that brain inflammation participates in the pathogenesis o...
Converging lines of evidence suggest that neuroinflammatory processes may account for the progressiv...
The principal pathology of Alzheimer′s disease includes neuronal extracellular deposition of amyloid...
Evidence suggests that various forms of α-synuclein- (αSyn-) mediated microglial activation are asso...
Microglia plays an important role in mediating neuroinflammation in Alzheimer's disease (AD). I...
The complex pathogenesis of Alzheimer’s disease (AD) involves multiple contributing factors, includi...
Inhibition of dendritic cell (DC) migration into tissues and secondary lymphoid organs is an efficie...
Cuprizone (Cup) is a copper chelating agent frequently used to study factors that affect oligodendro...
Triptolide, a major bioactive ingredient of a widely used herbal medicine, has been shown to possess...
Neuropathic pain (NP) is an intractable clinical problem without satisfactory treatments. However, c...
Objective: Triptolide (TP) has been reported to suppress the expression of mitogen-activated protein...
Triptolide (T10), an extract from the traditional Chinese herb, Tripterygium wilfordii Hook F (TWHF)...
Aldose reductase (AR) has a key role in several inflammatory diseases: diabetes, cancer and cardiova...
Evidence shows that an abnormal deposition of amyloid beta-peptide25-35 (Aβ25-35) was the primary ca...