Effect of botulinum toxin-A on secretion of parasympathetic denervated rabbit submandibular gland

BTX-A后1、2、4、12周时,静息状态颌下腺分泌量均较失副交感神经的对侧分别减少38.8%、56.5%、47.7%和38.6%,并且差异均有统计学意义(P<0.05);进食状态颌下腺分泌量均较失副交感神经的对侧减少,1周时减少46.2%,差异有统计学意义(P<0.05);分泌液中淀粉酶、钠、钾、氯离子及蛋白浓度无明显变化.结论 兔失副交感神经颌下腺内局部注射BTX-A可以抑制颌下腺的分泌.To investigate the effect of botulinum toxin-A (BTX-A) on secretion of parasympathetic denervated rabbit submandibular gland.Twenty-four rabbits were divided into 3 groups: control (n = 4), parasympathetic denervated submandibular gland (n = 4), and parasympathetic denervated submandibular gland with 5 U BTX-A injection (n = 16). Secretion flow was measured by Schirmer test. Composition of saliva was detected by biochemical method.Secretion of parasympathetic denervated submandibular gland increased by 139.0% in rest time (P < 0.01), but decreased by 64.2% in feeding time (P < 0.01) compared with controls. Secretion of submandibular gland decreased in rest time 1, 2, 4, and 12 weeks after BTX-A injection compared with that of parasympathetic denervated submandibular gland without injection (P < 0.05), which was also the same in feeding time 1 and 2 week after injection (P < 0.05). The concentrations of amylase, sodium, potassium, chloride and protein of saliva were not changed after BTX-A injection.BTX-A could decrease the secretion of parasympathetic denervated submandibular gland.PubMed中文核心期刊要目总览(PKU)中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)09548-5524