miR-342-5p Decreases Ankyrin G Levels in Alzheimer's Disease Transgenic Mouse Models

MicroRNA alterations and axonopathy have been reported in patients with Alzheimer's disease (AD) and in AD mouse models. We now report that miR-342-5p is upregulated in APP/PS1, PS1 Delta E9, and PS1-M146V transgenic AD mice, and that this upregulation is mechanistically linked to elevated beta-catenin, c-Myc, and interferon regulatory factor-9. The increased miR-342-5p downregulates the expression of ankyrin G (AnkG), a protein that is known to play a critical role at the axon initial segment. Thus, a specific miRNA alteration may contribute to AD axonopathy by downregulating AnkG.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000331166800004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Cell BiologySCI(E)PubMed15ARTICLEyanzhang@pku.edu.cn2264-270