Diversified syntheses of multifunctionalized thiazole derivatives via regioselective and programmed C-H activation

The sequential construction of diversified multifunctionalized thiazole derivatives through Pd-catalyzed regioselective C-H alkenylation has been accomplished. This versatile approach provides the diversified thiazole derivatives featuring orthogonal substitution patterns at the C-2, C-4 and C-5 positions frommono-substituted (2- or 4-substituted) thiazole derivatives or even more challenging simple thiazole.Chemistry, MultidisciplinarySCI(E)PubMed0ARTICLEzshi@pku.edu.cn224599-46025