Characteristics of blood gas analysis of sepsis patients and its correlation with the prognosis

目的：总结分析脓毒症患者的血气分析特点以及和预后的相关性。方法收集航天中心医院急诊监护收治的脓毒症患者临床资料和血气分析结果，分析不同病情、不同转归病人的血气特点。结果①入ICU早期，脓毒症、严重脓毒症、脓毒症休克三组间PH和血乳酸水平差异有显著性（P<0.01），病情越重，PH越低，乳酸越高；②存活组患者后期（出ICU时）的PH显著高于早期（入ICU时），乳酸（LAC）水平显著低于早期,P <0.01；病死组患者后期乳酸（LAC）水平显著高于早期；③存活组PH在早期和后期均显著高于病死组,P <0.01；存活组乳酸水平早期和后期均显著低于病死组,P <0.01。结论脓毒症患者PH越低，乳酸越高，预示病情越严重；且存活组和病死组随着病程发展，PH和乳酸向相反方向发展。Objective To analyzes blood gas analysis of sepsis patients and find its characteristics and its correlation with prognosis. Methods Sepsis patients’data was collected in the emergency intensive care unit (ICU) and analyzed based on different conditions and the characteristics of blood gas. Results ① In ICU early stage, the differences of pH and blood lactate among sepsis group, severe sepsis group and septic shock group were significant P < 0.01. The more severe the patient was, the lower the pH was, and the higher the lactate level was; ② Survivors’pH in ICU late stage was significantly lower than that of early stage, and lactate(LAC) levels were significantly lower than that of early stage P < 0.01; non-survivors’lactate (LAC) in later stage was significantly higher than that in early stage; ③ Survivors’pH were significantly higher than non-survivors in the early and late stage P < 0.01; Survivors’lactic acid levels were significantly lower than non-survivors in the early and late stage P < 0.01. Conclusion The lower the sepsis patients’pH is, the higher the lactic acid is, indicating a more severe condition. pH and lactate in the survivors and non-survivors change to opposite direction.北京大学人民医院研究与发展基金中国科技核心期刊(ISTIC)010884-88