Diagnosis and therapy of Pseudomyxoma Peritonei

目的 探讨腹膜假性黏液瘤的诊断和治疗.方法 总结32例患者的诊断及治疗过程,并复习文献.结果 所有患者术后未发现淋巴结及肝、肺等处转移,存活30例,死亡2例,术后严重并发症12例,包括肠瘘7例、低血糖昏迷1例,肠梗阻2例,消化道出血1例,肾功能衰竭1例.11例患者接受了不同方法的化疗,全身化疗6例,腹腔化疗5例,腹腔热灌注化疗8例;高频热疗1例.术后随访率80%(26/32),随访时间12～24个月,存活5年1例.结论 腹膜假性黏液瘤临床少见,诊断困难,影像学检查有助于诊断;治疗以手术为主,辅以化疗和/或放疗等.Objective To investigate the diagnosis and treatment of pseudomyxoma peritonei (PMP).Methods Retrospective study was made for 32 cases of PIMP.Results Main clinical presentations included abdominal pain, distention, mass and wasting of whole body.Uhrasonography showed heterogeneous ascites in 10 cases.Level of CEA elevated in 26 cases.All patients were performed an operation.Primary tumor was proved pathologically: 20 cases of appendiceal mutinous carcinoma, 2 eases of ovarian mutinous carcinoma and 1 case of descending colon mutinous carcinoma.Surgical procedure included resection of primary tumour, omenteetomy, removal of mucinous ascites and combined resection of organs involved.Postoperative adjuvant chemotherapy and/or radiotherapy was added.Conclusions PMP is a rare condition and difficult to diagnosis.Imaging examination and CEA may help make a diagnosis.Treatment of PMP is mainly surgical operation and adjuvant therapy.中国科技核心期刊(ISTIC)06539-540