Neuropathologic processes such as cerebral ischemia can enhance neurogenesis. Angiopoietin-1 (Ang1) emerges as a critical regulator of physiological and pathological angiogenesis during embryonic and postnatal life. Although Ang1 could protect peripheral vasculature from vascular leakage following ischemic injury, the role of Ang1 in long-term neurological recovery after ischemic stroke remains elusive. This study aims to examine whether Ang1 overexpression via lentivirus-mediated gene transfer enhances neurovascular remodeling and improves functional outcome in a rat model of focal cerebral ischemia. Our results demonstrated that lentivirus-mediated Ang1 gene transfer led to improved neurological behavior and reduced infarction volume, and...
Objective: To observe the protective effect of angiopoietin-1 (Ang-1) on the blood brain barrier (BB...
Background: We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angio...
BACKGROUND: We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angio...
In cerebral ischemia, the induction of angiogenesis may represent a natural defense mechanism that e...
In cerebral ischemia, the induction of angiogenesis may represent a natural defense mechanism that e...
<div><p>An angiogenesis factor, angiopoietin-1 (Ang1), is associated with the blood-brain barrier (B...
International audienceAlthough angiopoietin-1 (Ang-1) is recognized as an endothelial growth factor,...
Purpose Microvascular endothelial integrity is important for maintaining the blood-brain barrier (BB...
In regions of adult neurogenesis, neural progenitor cells (NPCs) are found in close proximity to blo...
The brain vascular system is composed of specialized endothelial cells, which regulate the movement ...
AIMS: Given the impact of vascular injuries and oedema on brain damage caused during stroke, vascula...
Clinical studies report that low circulating angiopoietin-1 concentration at presentation predicts w...
Ischemic stroke is a leading cause of death and disability worldwide with effective acute thrombolyt...
Background and Purpose—A better understanding of angiogenic factors and their effects on cerebral an...
Abstract Background Angiopoietin-1 (Ang-1) and -2 (Ang-2) are keyplayers in the regulation of endoth...
Objective: To observe the protective effect of angiopoietin-1 (Ang-1) on the blood brain barrier (BB...
Background: We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angio...
BACKGROUND: We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angio...
In cerebral ischemia, the induction of angiogenesis may represent a natural defense mechanism that e...
In cerebral ischemia, the induction of angiogenesis may represent a natural defense mechanism that e...
<div><p>An angiogenesis factor, angiopoietin-1 (Ang1), is associated with the blood-brain barrier (B...
International audienceAlthough angiopoietin-1 (Ang-1) is recognized as an endothelial growth factor,...
Purpose Microvascular endothelial integrity is important for maintaining the blood-brain barrier (BB...
In regions of adult neurogenesis, neural progenitor cells (NPCs) are found in close proximity to blo...
The brain vascular system is composed of specialized endothelial cells, which regulate the movement ...
AIMS: Given the impact of vascular injuries and oedema on brain damage caused during stroke, vascula...
Clinical studies report that low circulating angiopoietin-1 concentration at presentation predicts w...
Ischemic stroke is a leading cause of death and disability worldwide with effective acute thrombolyt...
Background and Purpose—A better understanding of angiogenic factors and their effects on cerebral an...
Abstract Background Angiopoietin-1 (Ang-1) and -2 (Ang-2) are keyplayers in the regulation of endoth...
Objective: To observe the protective effect of angiopoietin-1 (Ang-1) on the blood brain barrier (BB...
Background: We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angio...
BACKGROUND: We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angio...