Optimal intervention time of vagal stimulation attenuating myocardial ischemia/reperfusion injury in rats
- Wang, Qiang
- Li, Rui-Ping
- Xue, Fu-Shan
- Wang, Shi-Yu
- Cui, Xin-Long
- Cheng, Yi
- Liu, Gao-Pu
- Liao, Xu
DOIAbstract
To determine the optimal intervention time of the vagal stimulation (VS) attenuating myocardial ischemia/reperfusion injury (IRI). One hundred and twenty male SD rats were randomly allocated into six groups: sham group, IRI group, the VS performed at 15 min of ischemia (VSI15) group, the VS performed immediately before reperfusion (VSR0) group, the VS performed at 30 min of reperfusion (VSR30) group, and the VS performed at 60 min of reperfusion (VSR60) group. Rats in each group were further allocated into subgroups A and B. In each group, the hemodynamics and ventricular arrhythmias were continuously observed. In the subgroup A, serum inflammatory cytokine levels were tested, and infarct size was assessed. In the subgroup B, myocardial ...
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