Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida

Shen, Shi
Zhu, Huajie
Chen, Dawei
Liu, Dong
van Ofwegen, Leen
Proksch, Peter
Lin, Wenhan

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Publication date

January 2012

DOI

10.1016/j.tetlet.2012.08.049

Publisher

四面体通讯

ISSN

0040-4039

Journal

issn:0040-4039

Citation count (estimate)

Abstract

Five new cembrane-based diterpenoids, namely pavidolides A-E (1-5) were isolated from the marine soft coral Sinularia pavida, together with sarcophytin and chatancin. The structures of new compounds were determined on the basis of extensive spectroscopic data analysis. Pavidolide B (2) possesses an unprecedented 6,5,7-tricarbocyclic nucleus, whereas pavidolide C (3) is characteristic of an unusual C-5 and C-9 conjuncted cembranoid. Pavidolides C and D showed moderate antifouling activity against the larval settlement of barnacle Balanus amphitrite, while pavidolides B and C exhibited inhibitory activity against the human leukemia cell line HL-60. (C) 2012 Elsevier Ltd. All rights reserved.http://gateway.webofknowledge.com/gateway/Gateway.cg...

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Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida

Abstract

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Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida

Abstract

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