Synthesis of the cycloheptannelated indole fragment of dragmacidin E

Wang, Bin
Qin, Hua
Zhang, Fengying
Jia, Yanxing

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Publication date

January 2014

DOI

10.1016/j.tetlet.2014.01.063

Publisher

四面体通讯

ISSN

0040-4039

Journal

issn:0040-4039

Citation count (estimate)

Abstract

Synthesis of the pivotal cycloheptannelated indole fragment of indole alkaloid dragmacidin E is achieved. The synthesis features a Pd-catalyzed indole synthesis reaction for the preparation of 3,7-disubstituted indole, a regioselective intramolecular Friedel Crafts reaction for the construction of the 3,4-bridged cycloheptannelated indole skeleton, and a coupling reaction of vinyl triflate with diorganocuprate. (C) 2014 Elsevier Ltd. All rights reserved.Chemistry, OrganicSCI(E)3ARTICLEyxjia@bjmu.edu.cn91561-15635

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Synthesis of the cycloheptannelated indole fragment of dragmacidin E

Abstract

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Synthesis of the cycloheptannelated indole fragment of dragmacidin E

Abstract

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