Identification of the metabolites of baicalein in human plasma

Guo, Xiao-Yu
Yang, Lin
Chen, Ying
Wang, Qi-Fang
Sun, Qi-Shi
Che, Yi-Xin
Che, Qing-Ming

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Publication date

January 2011

DOI

10.1080/10286020.2011.599321

Publisher

journal of asian natural products research

ISSN

1028-6020

Journal

1028-6020

Citation count (estimate)

Abstract

The metabolites of baicalein in human plasma were investigated after taking baicalein, which is one of the main bioactive flavones in Scutellaria baicalensis Georgi. Five metabolites (M1-M5) together with the parent drug baicalein (P) were detected and identified by the HPLC-diode-array detector (DAD) and LC-MS/MS methods. Among them, 7-methoxybaicalein 6-O-glucuronide (M5) is a new metabolite. Based on the results, the proposed metabolic pathway of baicalein in humans was inferred.Plant SciencesChemistry, AppliedChemistry, MedicinalPharmacology & PharmacySCI(E)PubMed3ARTICLE9861-8681

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Identification of the metabolites of baicalein in human plasma

Abstract

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Identification of the metabolites of baicalein in human plasma

Abstract

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