Spectral and photophysical studies on the inclusion complexation between Triton X-100 and beta-cyclodextrin: A competitive method using a substituted 3H-indole probe

We report herein the interaction of the nonionic surfactant Triton X-100 with beta-cyclodextrin (beta-CD) using 2-(p-aminophenyl)-3,3-dimethyl-5carboethyoxy-3H-indole (1) as a fluorescent probe through a competitive method. The formation of 1:1 and 1:2 (guest:host) inclusion complexes was confirmed and the association constants were estimated. Using Triton X-100 itself as a probe, the interaction pattern and the association constants obtained were in agreement with those sensed by 1. Furthermore, the binding site of Triton X-100 with beta-CD was investigated. It was found that the entire hydrophobic part of Triton X-100 was included into the cavity of beta-CD. For comparison, we also employed 1 as a probe to study the interaction between Brij 56 and beta-CD. The above results strongly suggest that molecule 1 is a good candidate acting as a probe to study the inclusion complex between a non-fluorescent guest and cyclodextrin. (C) 2007 Elsevier B.V. All rights reserved.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000252910100014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Chemistry, PhysicalSCI(E)17ARTICLE2-3178-18619